New Hypotheses and Unanswered Questions in Running Injury Research – comment on Nigg et al.

James Becker


After critical evaluation of the evidence, Nigg et al.’s target article reject currently discussed hypotheses regarding relationships between impact forces, pronation, and running injuries.  In doing so, they highlight methodological questions underlying research in this field.  This commentary focuses on three such questions including: how are impact forces and the relationship between impact and injury being quantified, what are the methods currently used to measure foot pronation and what are metrics being extracted, and the importance of focusing on individual response patterns.   Each of these areas represents important venues for continued development in the field of running biomechanics and running injuries.


impact forces; frequency analysis; pronation; single subject analysis

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Bates, B. (1996). Single-subject methodology: An alternative approach. Medicine & Science in Sports & Exercise, 28(5), 631–638.

Bates, B., Dufek, J., & Davis, H. (1992). The effect of trial size on statistical power. Medicine & Science in Sports & Exercise1, 24(9), 1059–1068.

Bates, B., Osternig, L., & Sawhill, J. (1983). An assessment of subject variability, subject-shoe ineraction, and the evaluation of running shoes using ground reaction force data. Journal of Biomechanics, 16(3), 181–191.

Becker, J., James, S., Wayner, R., Osternig, L., & Chou, L.-S. (2017). Biomechanical Factors Associated With Achilles Tendinopathy and Medial Tibial Stress Syndrome in Runners. The American Journal of Sports Medicine, 45(11), 2614–2621.

Besier, T., Fredericson, M., Gold, G., Beaupre, G., & Delp, S. L. (2009). Knee muscle forces during walking and running in patellofemoral pain patients and pain free controls. Journal of Biomechanics, 42(7), 898–905.

Boyer, K. A., & Nigg, B. (2006). Muscle Tuning During Running: Implications of an Un-tuned Landing. Journal of Biomechanical Engineering, 128(6), 815.

Boyer, K. A., & Nigg, B. M. (2004). Muscle activity in the leg is tuned in response to impact force characteristics. Journal of Biomechanics, 37(10), 1583–1588.

Bredeweg, S. W., Buist, I., & Kluitenberg, B. (2013). Differences in kinetic variables between injured and noninjured novice runners: a prospective cohort stud. Journal of Science and Medicine in Sport, 16, 205–210.

Caster, B., & Bates, B. (1995). The assessment of mechanical and neuromuscular response strategies during landing. Medicine & Science in Sports & Exercise, 27(5), 736–744.

Davis, I. S., Bowser, B. J., & Mullineaux, D. R. (2016). Greater vertical impact loading in female runners with medically diagnosed injuries: A prospective investigation. British Journal of Sports Medicine, 50(14), 887–892.

Dufek, J., & Bates, B. (1991). Dynamic performance assessment of selected sport shoes on impact forces. Medicine & Science in Sports & Exercise, 23(9), 1062–1067.

Dufek, J., Bates, B., Stergiou, N., & James, C. R. (1995). Interactive effects between group and single subject response patterns. Human Movement Science, 14, 301–323.

Edwards, W. B., Gillette, J. C., Thomas, J. M., & Derrick, T. R. (2008). Internal femoral forces and moments during running: Implications for stress fracture development. Clinical Biomechanics, 23(10), 1269–1278.

Edwards, W. B., Taylor, D., Rudolphi, T. J., Gillette, J. C., & Derrick, T. R. (2009). Effects of stride length and running mileage on a probabilistic stress fracture model. Medicine and Science in Sports and Exercise, 41(12), 2177–2184.

Firminger, C., Fung, A., Loundagin, L., & Edwards, W. B. (2017). Effects of footwear and stride length on metatarsal strains and failure in running. Clinical Biomechanics, 49, 8–15.

Foch, E., & Milner, C. E. (2014). The influence of iliotibial band syndrome history on running biomechanics examined via principal components analysis. Journal of Biomechanics, 47(1), 81–86.

Gruber, A., Davis, I., & Hamill, J. (2011). Frequency Content of the Vertical Ground Reaction Force Component During Rearfoot and Forefoot Running Patterns. Medicine & Science in Sports & Exercise, 43(5), 60.

Gruber, A., Edwards, W., Hamill, J., Derrick, T., & Boyer, K. (2015). Ground Reaction Forces in Rearfoot and Forefoot Running Assessed By a Continuous Wavelet Transform. Medicine & Science in Sports & Exercise, 47(5S), 710.

Hamill, J., Miller, R., Noehren, B., & Davis, I. (2008). A prospective study of iliotibial band strain in runners. Clinical Biomechanics, 23(8), 1018–1025.

Messier, S., Martin, D., Mihalko, S., Ip, E., DeVita, P., Cannon, W., … Seay, J. (2016). A 2-Year Prospective Observational Study to Determine The Etiologic Factors Associated with Overuse Running Injuries. Medicine & Science in Sports & Exercise, 48(5S), 170–171.

Nigg, B., Mohr, M., & Nigg, S. (2017). Muscle tuning and preferred movement path - a paradigm shift. Current Issues in Sport Science, 2.

O’Connor, K. M. O., & Hamill, J. (2005). Frontal Plan Moments Do Not Accurately Reflect Ankle Dynamics During Running. Journal of Applied Biomechanics, 21, 85–95.

Phinyomark, A., Hettinga, B. A., Osis, S., & Ferber, R. (2015). Do intermediate- and higher-order principal components contain useful information to detect subtle changes in lower extremity biomechanics during running? Human Movement Science, 44, 91–101.

Reboussin, D., & Moran, T. (1996). Statistical consideration in the use and analysis of single-subject designs. Medicine & Science in Sports & Exercise, 28(5), 639–644.

Rodrigues, P., TenBroek, T., & Hamill, J. (2013). Runners with anterior knee pain use a greater percentage of their available pronation range of motion. Journal of Applied Biomechanics, 29(2), 141–146.

Schot, P. K., Bates, B. T., & Dufek, J. S. (1994). Bilateral performance symmetry during drop landing: a kinetic analysis. Medicine and Science in Sports and Exercise, 26(9), 1153–9.

Shorten, M., & Mientjes, M. I. V. (2011). The “heel impact” force peak during running is neither “heel” nor “impact” and does not quantify shoe cushioning effects. Footwear Science, 3(1), 41–58.

Willems, T. M., Witvrouw, E., De Cock, A., & De Clercq, D. (2007). Gait-related risk factors for exercise-related lower-leg pain during shod running. Medicine and Science in Sports and Exercise, 39(2), 330–339.


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